IGHE and atopic eczema: IFN-γ regulates approximately 500 genes, including increased transcription of antigen-presenting cells’ genes, differentiation of naïve CD4 + T cells towards Th1 cell direction, increased apoptosis and B cell response, increased immunoglobulin heavy chain production (increased IgG and decreased IgE), and the regulation of various inflammatory cells cytokines and adhesion molecules, also important for atopic dermatitis [2].