NF1 and malignant peripheral nerve sheath tumor: Studies carried out on NF1-null cells derived from malignant peripheral nerve sheath tumors (MPNST) showing RAS cascade hyperactivation were characterized by a deep phosphoproteome remodeling [18], and the phosphoproteome was assessed by high throughput mass spectrometry also in NS and NS with multiple lentigines (NSML) [19,20,21].