Xue et al. showed that knocking down RTN4 suppressed human colorectal cancer cell growth via cell cycle arrest at the G0/G1 phase [46] and Pathak et al. reported that RTN4 knockdown decelerated cancer proliferation and enhanced paclitaxel-induced cytotoxicity mediated by AKT pathways [47]. The gene discussed is RTN4; the disease is colorectal cancer.