NUP98 and cataract: In the present work, we report the first observation of biallelic NUP98 germline variants in two siblings presenting sparse eyebrows/eyelashes, bilateral cataracts, hypogonadism, skeletal defects, premature aging signs, a picture reminiscent of both Rothmund–Thomson syndrome type 2 (RTS2, OMIM#268400) [9,18,19], and RTS type 1 (RTS1, OMIM#618625) [9,20].