PGR and amyotrophic lateral sclerosis: The BioCarta mPR (membrane progesterone receptor) pathway (p-value = 6.27 ×10−5, FDR = 0.009), which involves the oocyte maturation by progesterone, is the highest ALS-associated gene set among the developmental-related gene sets, along with the immune-response BioCarta CSK pathway (p-value = 5.02 ×10−5, FDR = 0.009), covered in the previous section.