A pathological hallmark of ALS is the aberrant misfolding, aggregation, and deposition of protein inclusions formed by TAR DNA-binding protein of 43 kDa (TDP-43), Cu/Zn superoxide dismutase (SOD1), or fused in sarcoma (FUS) in motor neurons [76]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.