The GS-GWAS results provide potential links of these to motor neurodegeneration and to the ALS disease-associated protein, TAR DNA-binding protein of 43 kDa (TDP-43), mainly deriving from nervous system-related gene sets, such as the BioCarta CREB, Shh, DREAM, CK1 and AGPCR pathways. The gene discussed is SHH; the disease is amyotrophic lateral sclerosis.