Lastly, integrins—cell adhesion transmembrane receptors—(PID integrin cs pathway p-value = 0.005, FDR = 0.148; PID AVB3 integrin pathway p-value = 0.012034, FDR = 0.235) have been previously associated with cytokine activation as well as playing a critical role in infection, leukocyte recruitment, inflammation, angiogenesis and immunological signaling  [48]. This evidence concerns the gene MTA2 and infection.