It is clear that the most benign lesions present the alteration of v-Raf murine sarcoma viral oncogene homolog B (BRAF) in the codon V600E (that is sufficient for the nevus formation), but for melanoma development, BRAF mutation is not sufficient because the disease progression is bound to concomitant alteration in other genes involved in the most important cellular processes [21,22]. The gene discussed is BRAF; the disease is melanoma.