In addition to promote Rac1 binding to FilaminA, the RhoGDI2-Rac1 axis is also involved in another signaling pathway in GC since suppressing the expression of RhoGDI2 repressed the Rac1/Pak1/LIMK1 axis, which is involved in EMT, cell migration and invasion in multiple human cancers [42,43]. Here, RAC1 is linked to cancer.