A recent report claims that synergistic effects of traditional Chinese medicines Euphorbia Pekinesis and Glycyrrhiza glabra against HCC ascites in mice models is due to the downregulation of the expression of RhoGDI2 and Frk (Fyn-related kinase), a member of the Src non-receptor tyrosine kinase family. This evidence concerns the gene ARHGDIB and hepatocellular carcinoma.