DUOXA1 and cyclic hematopoiesis: Ultimately, the crucial role of DUOX1 in human thyroid function was demonstrated in patients with congenital hypothyroidism (CH): two heterozygous missense mutations in DUOX1 and DUOXA1 in two patients can cause CH through disrupting the coordination of DUOX1 and DUOXA1 in the generation of H2O2.