In addition, RTA dh404 promoted or repressed genes related to autophagy in cancer cells, including four genes (SQSTM1(p62), MAP1LC3B(LC3B), ATG5, and ATG12) in GBM8401 cells and two genes (SQSTM1 (p62) and MAP1LC3B (LC3B)) in U87MG cells. The gene discussed is ATG12; the disease is cancer.