In general, IL-10 is mainly produced by Th2, Th1, Treg [178], and Th17, and also by CD8+ T cells, monocytes, macrophages, DCs [179], B cells [180], mast cells, eosinophils [181], keratinocytes, epithelial cells, and even some tumor cells [182,183]. Here, CD8A is linked to neoplasm.