IFN-γ production by NK, NKT, CD8+ T, Th1, and γδ T cells stimulates and enhances immunorecognition, recruitment of immune cells to tumor sites and subsequently increases the ability to kill tumor cells [406], by improving the anti-proliferative status of cancer cells (growth inhibition, cell death, autophagy) [415], tumor cell antigenicity, and metastasis reduction by up-regulating fibronectin [155]. This evidence concerns the gene CD8A and neoplasm.