TUBB and Alagille syndrome: The molecular diagnosis validated the clinical hypothesis in five patients: hereditary Lymphedema (rWGS_5), mitochondrial depletion syndrome (rWGS_9), Alagille syndrome (rWGS_14), TUBB-related spectrum syndrome (rWGS_18) and 3-hydroxy-3-methylglutaryl-Coa lyase deficiency (rWGS_19).