Human immunoregulatory genes homologous to the rat Fcgr2b gene that we have identified as a molecular marker for elevated neuropathic pain tolerance in ARDs are expressed at increased rates mostly in conventional, monocyte-derived, and plasmacytoid dendritic cells as well as macrophages [233], which occur in most tissues, where they are critical to tissue homeostasis [234]. The gene discussed is FCGR2B; the disease is acute respiratory distress syndrome.