Four months of exposure to HFD (IR-HG mice) induced obesity (Figure 2a), hyperglycemia (Figure 2b), hyperinsulinemia (Figure 2c) and increased serum plasminogen activator inhibitor 1 (PAI-1) levels (Figure 2d), which contribute to the worsening of the (hypo)fibrinolytic state of diabetic patients [36] and are also associated with major adverse cardiovascular events (MACE) [37]. The gene discussed is SERPINE1; the disease is obesity due to melanocortin 4 receptor deficiency.