SERPINE1 and Hyperinsulinemia: Four months of exposure to HFD (IR-HG mice) induced obesity (Figure 2a), hyperglycemia (Figure 2b), hyperinsulinemia (Figure 2c) and increased serum plasminogen activator inhibitor 1 (PAI-1) levels (Figure 2d), which contribute to the worsening of the (hypo)fibrinolytic state of diabetic patients [36] and are also associated with major adverse cardiovascular events (MACE) [37].