CD8A and neoplasm: Transcriptomic features of primary tumor samples showed that patients with SF loss had an immune-suppressive tumor microenvironment (TME), including fewer CD8 T cells and M1 macrophage cells, a higher proportion of exhausted immune types, and downregulation of the immune-related gene signatures from the IMmotion150 [5] and Javelin101 studies [14] as well as anti-tumor immunity-related Th1 scores compared to those without SF loss.