Among the tumour types investigated in this study, CALCRL was predominantly expressed in all types of thyroid carcinomas, as well as parathyroid adenomas, small-cell lung cancers, large cell neuroendocrine carcinomas of the lung, pancreatic neuroendocrine neoplasms, renal clear cell carcinomas, pheochromocytomas, lymphomas, and melanomas. Here, CALCRL is linked to pulmonary large cell neuroendocrine carcinoma.