To investigate the role of miR-15a in chronic pancreatitis, we first assessed miR-15a levels and its targets (YAP1 and BCL-2) upon the development of chronic pancreatitis in Ptf1aCreERTM and Ptf1aCreERTM;LSL-KRASG12D mice. The gene discussed is YAP1; the disease is chronic pancreatitis.