Tracing the fate of Tcf21-CreER+ cells under normal conditions as well as after various chronic liver injuries, that study found that Tcf21-CrER+ preferentially marked periportal and pericentral HSCs that were quiescent in the steady state but became activated in the DEN/CCL4-induced state, originating 85% of the CAFs in HCC [43]. The gene discussed is TCF21; the disease is hepatocellular carcinoma.