A novel trial that investigated the impact of the HCC TME on human-adipose MSCs (hA-MSCs) and predicted hA MSC intracellular miRNA’s role demonstrated that when cocultured with Huh7 cells, the MSCs substantially upregulated the expressions of CAF markers, including αSMA, vimentin, c-MYC, MMP2, VEGF and IL-6, and thus, the hA-MSCs could transdifferentiate into CAF-like phenotypes [48]. Here, IL6 is linked to hepatocellular carcinoma.