CAF-derived chemokine CCL5 enhances HCC metastasis through triggering of the HIF1α/ZEB1 pathwayHCC-derived CAFs promote migration and invasion of HCC cells and boosted metastasis to the lungs of NOD/SCID miceCAF-derived CCL5 inhibits ubiquitination and degradation of hypoxia-inducible factor 1 alpha (HIF1α) under normoxia, thereby upregulating the downstream gene zinc finger enhancer-binding protein 1 (ZEB1) and inducing epithelial mesenchymal transition (EMT). The gene discussed is HIF1A; the disease is hepatocellular carcinoma.