In line with this hypothesis, Rosso et al. [22] prepared glutaraldehyde-crosslinked hyaluronic acid submicron particles (200–400 nm) by a non-solvent emulsion method and demonstrated their effective uptake by prostate cancer cells LNCaP without any significant toxicity and high accumulation of hyaluronic acid on a tumor site in a xenograft mice model through active targeting with CD44, a 85 kDa transmembrane receptor overexpressed in most tumor cells. Here, CD44 is linked to neoplasm.