In addition, a transcriptional signature associated with central memory in autoimmune CD8 T cells has been shown to correlate with a poorer prognosis in two autoimmune diseases: antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and systemic lupus erythematosus (SLE) [29]. The gene discussed is CD8A; the disease is systemic lupus erythematosus.