CD8A and anti-neutrophil cytoplasmic antibody-associated vasculitis: In addition, a transcriptional signature associated with central memory in autoimmune CD8 T cells has been shown to correlate with a poorer prognosis in two autoimmune diseases: antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and systemic lupus erythematosus (SLE) [29].