TRH and nutritional deficiency disease: Moreover, as occurs in other NEB conditions such as fasting or malnutrition, the body weight loss of EC-fed mice was able to modulate the expression of hypothalamic feeding-regulatory peptides in such a way that the animals increased their food intake due in part to the resulting reduced levels of peptides with anorectic actions such as POMC in the ARC and TRH in the PVN [33,34,35].