BDNF and early-onset autosomal dominant Alzheimer disease: Furthermore, EC also modulates intracellular signaling pathways, such as the acetylcholinesterase activity in hippocampus and cerebral cortex, improves memory and cognitive processes, reduces neuronal degeneration through stimulation of trophic factors such as the brain-derived neurotrophic factor (BDNF), and prevents amyloid ß protein associations in hippocampus and cortex, arresting the progression of Alzheimer’s disease [14].