ATXN2, for example, is important for multiple cellular processes [36], including (1) repressing mTORC1 signaling pathway to limit cell size, protein synthesis, fat and glycogen utilization; (2) assisting mitochondrial autophagy and maintaining mitochondrial precursors, etc. One possibility that ATXN2 may alter glaucoma risk is through causing mitochondrial dysfunction, because one of the significant aspects in glaucoma pathogenesis is the structural and functional impairment of mitochondria in retinal ganglion cells and their axons and synapses [37]. The gene discussed is ATXN2; the disease is glaucoma.