AKT1 and head and neck carcinoma: For instance, S100A11 knockdown causes a decrease in phosphorylated PI3K, phosphorylated Akt, and phosphorylated mTOR and disturbs cell proliferation and migration in head and neck carcinoma cells, indicating that the upregulation of S100A11 activates the PI3K–Akt-mTOR pathway in these tumor cells [129].