Consistent with the role of UV damage repair deficit in ARMD, the mutation in ERCC6 gene, the key factor in transcription-coupled NER (TC-NER) for UV lesion repair, cause Cockayne syndrome (CS), an autosomal recessive disorder characterized by severely impaired physical and intellectual development, clinically recognized by features including photosensitivity, pigmentary retinopathy, and retinal degeneration [69]. The gene discussed is ERCC6; the disease is age-related macular degeneration.