MAM or pTHC exposure also induced alterations in the transcriptional regulation of the genes encoding for cannabinoid CB1 (Cnr1), dopamine D2 (Drd2) or D3 (Drd3) receptors at the level of PFC of adult rats, further confirming the hypothesis of DA–cannabinoid interaction as a molecular substrate of neurodevelopmental disorders [24]. This evidence concerns the gene DRD2 and neurodevelopmental disorder.