CD274 and non-small cell lung carcinoma: Further shotgun-metagenomics-based microbiome profiling in a large cohort of patients with advanced NSCLC (n = 338) treatment with first- or second-line ICIs revealed that baseline stool Akk is associated with increased objective response rates and overall survival in multivariate analyses, independent of PD-L1 expression, antibiotics, and performance status [152].