TLR9 and myelodysplastic syndrome: This colocalization was quantifiable with MDS cells having an average of 92% of ox-mtDNA bound to TLR9 compared to 72% in normal BM-MNCs (Figure 2B) with cytosolic concentration of ox-mtDNA, and TLR9 surface expression, significantly increased in the cytoplasm of MDS BM-MNCs, compared to healthy controls (Figure 2C).