In fact, besides the wild type allele G0, APOL1 gene has two variants named G1 and G2 that are indicated as Renal Risk Variants (RRVs) [82]; about 13% of African Americans carry two high-risk alleles (either G1/G1, G2/G2, or G1/G2), putting them at a 3- to 30-fold increased risk of developing future kidney disease. The gene discussed is APOL1; the disease is kidney disorder.