Having observed that PPARGC1A expression is robustly downregulated and lipid droplets accumulate when microRNA hsa-miR-193b-3p is overexpressed in HepG2 cells under hyperglycemia–hyperinsulinemia, we proceeded to analyze the expression of other genes involved in lipid metabolism and processing that might be affected. This evidence concerns the gene PPARGC1A and Hyperglycemia.