PPBP and fragile X syndrome: This means that VGB, TGB and GBP can be considered as applicable in those diseases in which oxidative stress is an important pathophysiological factor, e.g., diabetic neuropathy and retinopathy, FXS, HD, or spinal cord ischemia-reperfusion injury [24,29,30,33,35,36,41,48,51,52,53,54,55,56,57,58,61,65].