In fact, primary and metastatic colorectal tumourspheres showed three differential mRNA expressions (PPARG, CCL20 and IL-8) in response to oxaliplatin treatment, which all were underexpressed in primary colorectal tumourspheres, differentially to metastatic colorectal tumourspheres, creating a signature profile. The gene discussed is CXCL8; the disease is medical procedure.