Marine lectins may mediate multiple pathways, including the MAPK, Hippo, PI3K/Akt, lipid metabolism, and androgen pathways through AMPK crosstalk, to promote oncoVV replication in HCC in a cell-dependent manner, suggesting that key molecules in relevant signaling pathways had the potential to synergize with oncoVV-lectins to improve therapeutic efficacy. The gene discussed is AKT1; the disease is hepatocellular carcinoma.