M3G suppressed the proliferation, polarization, migration, and invasion of HepG2 cells in vitro by regulating the protein expression of cyclins D1, B, E and cleaved caspases-3 and caspase-3, Bax, p-JNK and p-p38, and by activating PTEN with decreased levels of p-AKT and MMP-2 and -9; while in vivo, M3G promoted apoptosis of liver cancer cells [58]. This evidence concerns the gene CASP3 and liver cancer.