MAP2 and Parkinson disease: However, evaluation of a set of candidate genes for PD (excluding those included in the 22 q11.2 deletion syndrome region and known PD- related genes) documented a greater burden in 22q11.2 DS patients with PD, including rare variants in Kruppel-like factor 1J (KLF1J), a regulator of the monoamine oxidase B expression, and microtubule associated protein 2 (MAP2), a cytoskeleton protein found in Lewy bodies.