In KS of the skin, we contribute (a) the participation of the delimiting CD34+SCs/TCs in the external layer of pre-existing blood vessels and around skin appendages in the formation of neovessels, behaving as resident mesenchymal/stromal cells capable of transdifferentiation into neovessel ECs and (b) the formation of two main types of initial neovessels in the early stages of KS, leading to progressive sarcomatous lesions. Here, CD34 is linked to Kaposi's sarcoma.