The main events of CD34+SC/TC participation in the formation of neovessels and the evolution of the latter in the KS stages can be summarized as follows (Figure 16): (1) In the very early stages of KS, CD34+SCs/TCs retain their characteristics in the external layer of pre-existing blood vessels and around skin appendages, with and without perivascular inflammatory infiltrates, which, when present, they encompass. Here, CD34 is linked to Kaposi's sarcoma.