MMP9 and Increased total eosinophil count: For example, ATP1B1 was previously included in transcriptomic cluster TAC3 of patients with moderate to high sputum eosinophilia in the U-BIOPRED cohort of T2-high asthma, playing a role in the epithelial sheathing, mucus secretion, and airway hyperreactivity, whereas RECK is a negative regulator of matrix metalloproteinase-9 (MMP-9), a significant MMP involved in airway remodeling.