ITGA4 and asthma: In contrast, the interacting proteins with the highest connectedness in the graph were related to asthma pathogenesis and include fusogenic protein genes (ICAM1, VCAM1, ITGA4, and their regulator, ELAVL1) as well as ILK, a β1 integrin-linked kinase involved in fibroblast migration, myofibroblast differentiation, and tissue remodeling [37].