CLC and asthma: Moreover, the differentially co-expressed genes, both up- and down-regulated in EA, were previously linked to asthma in the genome- (e.g., MRPL14 [31], ASB3 [23], RHOBTB2 [23]) and epigenome-wide (e.g., CLC [23], EPS15 [32], GPI [36], SRCRB4D [23], STRN4 [23]) association studies.