SP1 and asthma: Figure 2 shows a regulatory network of the differentially co-expressed genes, indicating their relation to asthma-relevant transcription factors: E2F1, SP1, YY1, MYC, FOS, EGR1, CTCF, and NFKB1 as well as microRNAs: miR-135b [38], miR-135a [39], miR-340 [30], and miR-223 [40], recently described as involved in asthma pathogenesis through, e.g., regulation of CXCL12, signaling via JAK/STAT pathway, expression of MIDI1, and subsequent mTOR signaling or release of proinflammatory CCL20 from bronchial epithelial cells.