Funaki et al. showed that protein 4.1R is a CADM1 downstream binding site in non-small cell lung cancer; that CADM1 can recruit protein 4.1R to the plasma membrane, promoting anchorage-independent growth of small cell lung cancer (SCLC) cells and influencing the development of small cell lung cancer; and that co-localization of the CADM1 protein 4.1R complex at the plasma membrane correlates with the pathological stage of small cell lung cancer and reflects the malignancy of small cell lung cancer pairs [49]. This evidence concerns the gene EPB41 and small cell lung carcinoma.