In breast cancer, DAL-1 (Differentially Expressed in Adenocarcinoma of the Lung)/4.1B can regulate substrate methylation via protein arginine N-methyltransferase 3 (PRMT3) and protein arginine methyltransferase 5 (PRMT5), while hypomethylation of cellular proteins, in turn, increases DAL-1/4.1B protein levels [58]. The gene discussed is PRMT5; the disease is breast carcinoma.