In Cohort II, none of the Igs differed between APOE4 carriers and non-carriers (Table S2), and although a similar trend toward an APOE4 allele-dependent effect was noted regarding IAPPO-IgA levels (Figure 1D), this trend was not significant either before or after controlling for T2D (p = 0.145 vs. p = 0.515, respectively). Here, CUBN is linked to type 2 diabetes mellitus.