IAPP and type 2 diabetes mellitus: Furthermore, higher blood levels of IAPP-autoantibodies have been found in T2D patients compared with non-diabetic subjects [25], and specific autoantibodies directed against IAPP oligomers (but not monomers or fibrils) have been exclusively found in diabetic patients [26], confirming the pathological relevance of the amyloidogenic peptide in T2D.