High expression of OXER1 in lung, liver, spleen, kidney, prostate, and breast cancer cells as well as in inflammatory cells (eosinophils, lymphocytes, monocytes, and neutrophils) and its activation by endogenous ligand 5-oxo-ETE mediated the intracellular actions in cell proliferation and survival, inflammatory responses, and steroidogenesis stimulation [91]. The gene discussed is OXER1; the disease is breast carcinoma.