ULK1 and breast carcinoma: Likewise, TRPM8 is also a predicted diagnostic indicator of breast cancer, which promotes metastatic potential by activating the Akt/GSK-3β signaling pathway and thus regulates the epithelial–mesenchymal transition [81] as well as cellular autophagy via activation of AMP-activated protein kinase (AMPK) and Unc-51 like autophagy activating kinase 1 (ULK1) [82].