Activated PKCα then phosphorylates Janus kinase 2 (JAK2), which drives non-canonical DDR1 signaling through the phosphorylation of signal transducers and activators of transcription 3 (STAT3), further upregulating the transcription of cell cycle regulators, such as c-Myc and cyclin D, and promoting cancer cell proliferation. The gene discussed is STAT3; the disease is cancer.