IL10RB and skin disorder: On the other hand, IL-10Rβ activity can also be induced in some non-haematopoietic cells such as skin fibroblasts, keratinocytes and epithelial cells following LPS activation, which may indicate the advisability of the external application of certain preparations of natural origin, including ash leaves, for the treatment of chronic, difficult-to-heal wounds, atopic eczema, dermatitis or psoriasis [43,44,45].