COBLL1 (cordon-bleu WH2 repeat protein-like 1) gene is associated with neural tube formation [23], central obesity [24], fasting insulin [25], type 2 diabetes risk [26], blood lipids [27], CVD risk [28], gastric cancer [29], prostate cancer [30], and leukemia [31,32]. This evidence concerns the gene COBLL1 and type 2 diabetes mellitus.