Various cytokines and adhesion molecules, including interleukin (IL)-1, IL-2, IL-6, IL-8, IL-12, IL-18, TNF-α, and nerve growth factor, are abnormally expressed in the lesions of psoriasis patients, suggesting that psoriasis is associated with the release of NF-κB-regulated inflammatory cytokines [70]. The gene discussed is IL18; the disease is psoriasis.