Nowadays, the diagnosis of early preeclampsia is associated with the simultaneous occurrence of increased resistance in the blood flow of uterine arteries and disturbances in the angiogenesis process, which, to some extent, can be monitored using angiogenesis placental markers, such as soluble FMS-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PLGF). This evidence concerns the gene PGF and preeclampsia.