By comparison, analysis of the role of the unique genes in MCF7-ERβ1 cells revealed that the regulation of all but one of the hub genes (PPARG, HIPK2, ZFP36L1, HMGB2 and ALDH1A3) and of 12 more unique genes (ASCL1, ID3, GPNMB, SGK3, BAG3, WDR73, ALKBH1, HIGD1A, FGD3, ACAA2, DOCK8 and AGR3) reportedly favors inhibition of breast cancer cell proliferation and tumorigenicity, induction of cell death and/or better clinical outcome [48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64]. The gene discussed is HMGB2; the disease is breast cancer.