Downregulation of Bcl-2 expression and an increased Bax-to-Bcl-2 expression ratio may be associated with non-apoptotic cell death in the antiestrogen-responsive MCF7-WT and MCF7-ERβ1 cells in agreement with the previously reported induction of non-apoptotic cell death upon treatment of MCF7 cells with OHT and ICI 164 384 [88] and suppression of the pro-survival role of Bcl-2 in ERα-positive breast cancer cells by antiestrogens [89]. The gene discussed is ESR1; the disease is breast cancer.