S100A8 and cancer: In MCF7-WT cells, the regulation of the two unique hub genes (BCL2 and NKX3-1) and of five more unique genes (S100A8, TNFRSF11B, KRT10, DRAM1 and IRF1) is reportedly associated with anticancer effects, while the regulation of the remaining six unique genes (CADM1, KRT4, SQSTM1, HK2, DHCR24 and RAI14) is reportedly associated with cancer-promoting effects [35,36,37,38,39,40,41,42,43,44,45,46,47].