WNT16 and leiomyoma: These findings raise the intriguing possibility that MED12 mutations in the leiomyomas also induce changes in the expression of WNT16 in the adjacent myometrium, which further fuels tumorigenesis in mutated specimens; this possibility could account for the observation of multiplicity of tumors in MED12-mutated specimens compared to non-mutated tumors which are generally solitary [22].