The involvement of many proteins such as FN1, COL1A1, BMP7, CCND1, EZH2, HMGA2, AhR, and E2F1 shown in the protein–protein interaction networks are well known in leiomyoma pathogenesis [8,28,29,30,31,32]; others, such as SOX2, REN, PPARG, ABCB1, and NR3C1 are novel and require further investigation. This evidence concerns the gene HMGA2 and leiomyoma.