SYT2-CMS, SNAP25-CMS, VAMP1-CMS, UNC13A-CMS, RPH3A-CMS, and LAMA5-CMS are characterized by defects in the SNARE complex, and phenotypically similar to Lambert-Eaton myasthenic syndrome (LEMS). The gene discussed is RPH3A; the disease is Lambert-Eaton myasthenic syndrome.