TTR and familial amyloid neuropathy: More than 100 amyloidogenic TTR mutants lead to the formation of amyloidosis [46] such as familial amyloid polyneuropathy (FAP) [47], familial amyloid cardiomyopathy (FAC) [48] and central nervous system-associated amyloidosis (CNSA) [49,50,51], mainly depositing in the heart, lungs and peripheral nerves [52].