Amyloid protein aggregates, such as FUS and TDP-43 aggregations in Amyotrophic Lateral Sclerosis (ALS), Tau and Aβ aggregations in Alzheimer’s disease (AD), and α-synuclein fibrils in Parkinson’s disease (PD), are pathognomonic features of several neurodegenerative diseases [1,2]. The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.