In a xenograft mouse model study in which human bone marrow cells from patients with chronic myelomonocytic leukemia (CMML) were transplanted into mice, the co-expression of mutant ASXL1 and RUNX family transcription factor 1 (RUNX1) genes showed strong leukemic transformation, accompanying an increased expression of inhibitor of DNA binding 1 (ID1) gene [95]. This evidence concerns the gene ASXL1 and chronic myelomonocytic leukemia.