Galectin-3 contributes to various pathophysiological processes, including inflammation and fibrosis, cancer cell proliferation, adhesion, angiogenesis, cell migration, T-lymphocytes apoptosis and macrophage differentiation into infiltrative forms that stabilize tumor environments and polarization of tumor-associated macrophages [3,4,5,6,7,8]. The gene discussed is LGALS3; the disease is cancer.