In SCLC, MUC1-C activates the MYC pathway in classic NE SCLC-ASCL1 (SCLC-A), variant NE SCLC-NEUROD1 (SCLC-N) and non-NE SCLC-POU2F3 (SCLC-P) subtypes (Table 1) [100]. The gene discussed is ASCL1; the disease is small cell lung carcinoma.